I was on Depo for 4 shots. In that time, I lost my libido completely. It has been over 10 years, and it hasn't ever come back like it was. It took an additional year for my period to come back after I stopped taking the shots. I had a great amount of difficulty getting pregnant (several years later). And the worst of all was my VISION loss. By the end of the year, my vision was 20/60 with my glasses ON. I went from about 20/120 to 20/400 in that one year. It says somewhere in the fine print that it could do that. I just glazed over it as one of those-"it will never happen to me" kind of things. Since then, I have had very little vision changes. I cannot even see the speedometer in my car without my glasses, much less the other cars on the road. I wish I had never taken it at all.