Hi J.,
I'm going to go against the popular answers on this one. I have 4 girls and we make 5-6 hour trips frequently. With every one of my children, I have mixed up a couple of bottles of warm formula for the trip and used them all during the trips. When I get to our destination, I toss anything that is still in the bottles and start over. As we all know, recommendations for all types of things err way on the side of caution because no company wants to get sued. But I can tell you from years of experience, there is nothing wrong with going several hours with warm formula. I have never, not one time, had any problems with this. We also go to church and are gone for 3 hours sometimes. I do the same for those times and have never had any trouble. Nobody has ever gotten sick or poisoned or had any abdominal pain or diarrhea or vomiting or anything at all. I encourage you to do what makes you comfortable, of course, but I just wanted to share my experience with you. God bless.
-J.