I would think that it would depend on the meds that they give you. When I got my lasik done, I was on xanax and they gave me valium. I didn't care what they did. It wore off in a few hours. When I got my wisdom teeth pulled, I was given Tylenol w/ Codine (#3). That took care of the pain and didn't effect me. The first time I had taken it, it made me sleepy. Most doctors up here seem to like to give people vicodin. When I am on that, it makes me nauseous and out of it. I took it for cramps. I wasn't taking any kolonpin or xanax at the time. Those just seem to multiply the effects of anything else that I would take. I second the person who said to ask a pharmacist...they have been invaluable to me. If your surgery goes well for the wisdom teeth, like mine did, I only needed the Tylenol for the first day...that's a day of rest anyways...you'll need someone to take care of your son then. I ended up with a dry socket (probably from coughing since I caught brochitis at the same time), and then I need the pain meds again until the doctor fixed it. Okay, enough rambling. I think that you will do fine if you get the right meds to combine. The pharmacist can tell you that, and you could share that with the dentist that you prefer x.