I had terrible PUPPS the last month of my pregnancy. The rash was up and down both legs. It was miserable because I itched so bad I couldn't sleep- not that I was getting much at that point anyways. Regular lotion seemed to make it worse. I tried everything I was allowed to- Benadryl, hydrocortisone, calamine. The doctor finally prescribed a steroid cream which helped more than anything. The only thing the made it go away was having my son. Once I had him, it immediately disappeared.