My life is very much like Krista K's life! My husband is also a pilot, and is currently on a 19 day working, then 8-9 days off schedule. He was also gone for training for almost 2 months when our daughter was only 5 months old. Plus, we don't have any family here. So, I feel very much like a single mom when he is gone. In the beginning it was really hard, especially during training. After a few months it got easier, and I got into a routine. We also have a computer with a webcam at home, and a laptop for my husband so we can talk and see each other when he has internet access. He also has a cell phone, and we talk several times a day. Communication is key.
The biggest question I have for you, is how many days is he actually going to be gone/home at a time? Some over the road trucking companies have their drivers out for a month or more at a time, and some are home every week. Since he really wants to do that, maybe he can look for a job where he is home more often. You definitely need to talk to him about how you feel and how you think it will effect your kids. Sit down and have a calm discussion with him, and let him know you are afraid it will affect your marriage.
If you both agree that he should still do the OTR driving, then set up a routine, make sure you have great communication- even more important when your spouse is gone than it normally is, and do as much of the things that Krista is doing with your own kids. Also, it helps if he is anywhere within driving distance while he is on the road to take the kids and go see him sometimes. I do that sometimes, and my husband really appreciates that.
If you both decide that he shouldn't do the OTR driving, try to see if there are any driving jobs in the area that he would really enjoy. If you tell him that you don't want him to do it and he still does, then do the best you can, give it your best effort for a few months, and then let him know how it is going at that point.