Homemade gifts, to me, really say you care. Cookie plates are nice, as others have suggested. What about having your kids put their hand prints on some nice paper, write a special message to each caregiver, and put it in a nice frame. You can get pretty frames at dollar stores, and you could look up little snippets of poetry online, if you can't think of your own words. (I'm never good at "special sentiments", heh.) Another gift I've done in the past is potpourri sachets. You need 2 lace doilies per gift. Sew a bag out of muslin or cheesecloth, just smaller than the doily, and fill it with a nice scent of potpourri. Sew the bag closed, then sandwich it between the doilies. Thread ribbon in and out of the holes in the doilies, and tie a bow, or leave enough ribbon that they could hang.
If you can find a good sale, fleece no-sew blankets would be nice too. Just cut, fringe or tie, and you're done. A yard makes a good-sized lap blanket, perfect for snuggling on the couch.
Just let your imagination go, and you can make something really nice. Feel free to pick my brain more if you need to, heh.