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Has Anyone Taken Letrozole (Also Known as Femara) in Order to Get Pregnant?

I have not been having regular cycles since having my first child (now almost 3yrs). My doctor suggested that I take Letrozole/Femara in order to ovulate and hopefully get pregnant. I have not decided if I want to take it yet, and would really appreciate hearing from others who have taken Letrozole and/or Clomid (a similiar drug) before I make a decision. Thanks!

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I have taken clomid previously to get pregnant, but was unsuccessful. I had horrible mood swings for a few days after taking the medication. I have a friend that had taken to conceive her three children, a set of twins and a single. She didn't notice any difference in how she felt.

I would do the Clomid first. You can do several cycles with this and it won't harm you. As for the Letrozole this must be something new because I never heard of it. Good luck!!

K. B.

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Hi C.,

Yes I have taken Letrozole (Femara). To make a very long story short....I was on Clomid and different combinations of Clomid w/other drugs for almost a year with no sucess. I finally saw an IVF specialist and he suggested I try Letrozole as a last chance before recommending IVF. It worked on the first try and I have a gorgeous daughter that will turn 2 in a couple of days. My husband and I are wanting to have a second baby and are planning to try Letrozole again. Would you give me the name of your Dr. that suggested it? We are not from here (we had our daughter in Washington) and I would like to know a doctor that is familiar with using Letrozole. Best of luck to you. I hope that whatever you try will work quickly!

:) K. L.

I have taken clomid previously to get pregnant, but was unsuccessful. I had horrible mood swings for a few days after taking the medication. I have a friend that had taken to conceive her three children, a set of twins and a single. She didn't notice any difference in how she felt.

I would do the Clomid first. You can do several cycles with this and it won't harm you. As for the Letrozole this must be something new because I never heard of it. Good luck!!

K. B.

Let me first say I'm sorry you are going through this. Infertility and irregularity are terrible things to deal with when trying to conceive!

We are truly blessed to have our little miracles. After being told I'd never conceive many years ago... we proved them wrong!

It took 15 months and our first round of 50 mg of Clomid but Zack was on his way!

Jess was a different story... Here's our story.

We started trying for Jess in 2004.

We decided to seek medical help on April 25th, 2005.

On 5-8-05 (Mother's Day & CD-35) I started taking Prometrium to force AF into obeying. (Anov. cycle)

5-19-05 - 50-mg of Clomid CD-4 - 8. (15 day LP)

7-1-05 - 100-mg of Clomid CD-4 - 8. (13 day LP)

8-10-05 - 150-mg of Clomid CD-4 - 8. (16 day LP)

9-13-05 - 150-mg of Clomid CD-4 - 8. (18 day LP but possibly Anov)

10-14-05 - 200-mg of Prometrium.

10-27-05 - 200-mg of Clomid on CD-4 - 8. (17 day LP)

12-3-05 - 200-mg of Clomid on CD-4 - 8. (15 day LP)

We decided to try things without Dr's for awhile since I became MEAN on the last round of Clomid. LOL!

1-7-06 - No drugs. No Doctors. (20 day LP - Chem. Preg.)

2-22-06 - No drugs. No Doctors. (19 day LP)

We decided to try the holistic approach until we decided to move on to the RE.

4-14-06 - Vitex (16 day LP)

6-8-06 - 600-mg of Black Cohosh Root & 1000-mg of Vitex. (16 day LP)

8-1-06 - 600-mg of Black Cohosh Root & 1000-mg of Vitex. Again. (17 day LP)

9-14-06 - 600-mg of Black Cohosh Root, 1000-mg of Vitex, 99-mg of Potassium & Reflexology. HOLY CRAP!! IT WORKED!!!

I know that was extremely long but I thought it might be helpful to know that Clomid did work the first time but other methods worked the second time. Vitex is a natural herb that regulated me. If you are interested in herbal methods try reading "The Infertility Cure" by Randine Lewis. It has a test in the book you take to figure out what your deficiencies are and then it tells you what herbs to take for it. It also helps explain what all the herbs do, why they work, and how they do what they do.

If faced with having to take Clomid again I would. My side effects were not bad at all until I had maxed out what my OB would allow. I begged to stay on it longer than he recommended too. I wasn't ready to face that we would need additional help. I went back to work to pay for all of the infertility treatments I thought we would need. IUI was our next step. Within 3 days of starting my new job I conceived though. I firmly believe the holistic approach is what worked for us.

Sorry for the book. LOL!

I have taken Letrozole and Clomid in the past. A couple years ago my Reproductive Endocronologist told me that Letrozole was taken off the market by the FDA for fertility treatmeants and from that point on I didn't take it anymore. You may want to just make sure that it would be safe -double check with your doctor and do some research for yourself online. I ended up doing IVF and delieverd my second son in February. I hope things work out for you. I know how hard it is to wait for a child and try to navigate through doctors, drugs and treatments. Hang in there!

Tried Clomid with no results. 50mg did nothing and 100mg made me a crazed lunatic....
Letrozole is proven to produce more pregnancies and does not have all the bad side effects as Clomid. No luck with Clomid, but conceived my son on Letrozole (that is after surgery (ovarian Drilling)).
When I want to conceive again, I will go right to Letrozole. I refuse to be on Clomid again. It was horrible. If you have the option, choose Letrozole.
Good Luck..

I haven't taken Letrozole but I did take Clomid for three months and got pregnant after the last month. It is worth a try and definitely can't hurt.

I took Femara (brand name) and Follistim injections for 3 cycles and our son Christopher arrived 12/16/05!!! We saw a fabulous reproductive endocrinologist in Indianapolis. Femara and the risk of multiples is low, and our doctor monitored us VERY closely during the process! I wish you the best!!

Hi C....I took Clomid to get pregnant with my son. I worked like a charm. About 4 months after starting it. I don't remember any side effects from it. It was over 6 years ago, so I going on what I remember...I would say I would do it again if I had too. Good luck!


I have a two year old daughter. My husband and I have been trying to conceive (10months)and no luck. My doctor had me try the low dose asprin 80mg and that has not worked. She just recently gave us an option of clomid. She told us how it works and possible side effects. We decided to try it. I have only had one months worth and no side effects. I will let you know in about 2 weeks if it worked. We began to get concerned because it was so easy to conceive the first time. The nice thing about clomid is that is just recently went on the genetric list of medication and is only $9.00 at Walmart Pharmacy.

Clomid is a pretty typical 1st step for those trying to conceive. I took clomid for 6 cycles with no luck at all. But I know people who have taken it and were successful.

If you do decide to take it, I wouldn't do it for more than 3 cycles before "moving on to the next step."

I ended up going right to IVF and the next cycle started as an IVF, and became an IUI - both cycles were successful. If you're interested, I can let you know who my dr. was that helped us.

I took Clomid at 150 mg to get pregnant with all 3 kids. I don't have PCOS; I'm just for the most part anovulatory probably from too much running in my teens and 20s. It took 3 months for #1, 6 months for #2, and 2 months for #3. I had to finish BF my girls when they turned 1 year old before trying to get a period with Prometrium in order to take Clomid.

Good luck. I wish you success!

Hi C.! I too was on the clomid cycle, and it made me a raving lunny. We got pregnant on our 3rd cycle of letrozole and our little girl will be 2 in 3 weeks! When I get some more weight off, we will be going back to the fertility specialist to give it another shot. I did not have any shots in addition to the letrozole, and I had NONE of the side effects that I had with clomid. Our dr. told us that the risk of multiples witht he letrozole was not any greater than it happening naturally, so we were pretty comfortable with the drug. I also have PCOS and am taking metformin as well. It worked for me and my pregnancy was pretty good, if everything lines up right for you, I would try it!

I used Clomid (4 cycles at 50 mg) to conceive my daughter, now 16 months. We're trying again using Clomid, but it isn't working this time. I'm on my 3rd cycle of 150 mg and nothing, so my doc says we'll try 200mg next, then I have to see a fertility specialist. I would recommend Clomid. My doctor said if it doesn't work within 4-6 cycles, depending on your dosage, it isn't going to work. Anyway, best of luck to you. Hopefully we will both be pregnant soon!

Hi C.-
I'm sorry you are having to deal with the frustration of infertility. That rollercoaster ride is one I don't wish on anybody. I'd like to share my story to show you that if you want that baby badly, exhaust EVERY option for that bundle of joy. It is so worth it!! It WILL happen, one way or another if you persist (even if you have to finally move on to adoption, surrogacy, donor egg, etc.) Don't give up!!!

I conceived both of my children through ART methods. My daughter (almost 6 yrs.) was conceived through artificial insemination (IUI) on the 3rd attempt, no drugs(no Clomid or letrizol) when I was 35 yr. old. When trying for #2, we had a HORRIBLE time. We must have tried about 12 IUI's, some with Clomid, some with letrizol (Femara) and even one with the fertility shots (Follistim). Nothing worked. We went to IVF.

IVF #1-1 healthy embryo (we did PGD-it looks at 9 of the chromosomes-the ones that usually cause serious problems),no pg.
IVF#2-3 healthy embryos (PGD), got pg, m/c at 10 wks., not sure why.
IVF#3-4 embryos put in on day 3 (no PGD-my Dr. started feeling like there were problems with the PGD), got pg,m/c at 17 wks.-found out baby had severe chromosomal abnormalities.
Frozen Embryo Transfer (FET)- (had 4 embryos left over from last IVF), put all 4 in, got pg, had a healthy son 8/11/07. He was born 3 months early due to me having an uncommon problem during pg and getting very sick. He did great from the start and is still thriving!!

About the Femara (brand name) or letrizol, my Dr. doesn't like to use it anymore. It is actually a chemotherapy drug, odd, isn't it?? Anyway, I know my Dr. doesn't use it anymore and I'm not 100% sure (it has been 3 yrs. since I spoke to my Dr. about Femara) but I believe that it has been linked to early m/c. I think there may be a split in the infertility community on whether to use it or not, though.

I hope my post will give somebody hope and the willingness to pursue the dream of motherhood. The very best of luck to you.
Hang in there and don't give up!!

I took Clomid to get pregnant with #4. For me it worked on the first round. I also had a wonderful RE here in Indianapolis. Good luck.

I am lucky to have a period every 4 months on an average. After trying for 10 months, my Ob put me on Clomid 50mg days 5-9. I got pregnant on the first cycle and am now 6 month along. I was definately a miracle drug for me! Good luck!

I took Clomid 50mg to get pregnant. I was ovulating but my progestrone level was too low to sustain a pregnancy. The first month of taking it I got pregnant but had a miscarriage at 11 weeks. After recovering I took Clomid again but also did acupuncture and am now 16 weeks pregnant. With the first round of Clomid I did have some side effects (was mean and had hot flashes) but with the second round I didn't have any.

I would ALSO do EVERYTHING I COULD to find out how nutrition is related to infertility and what you BOTH need to be eating on a regular basis. You'll be amazed at what you can do WITHOUT meds by eating a proper diet. It's MORE than just "becuase I should". It's the WAY GOD DESIGNED US. When we fall away from that, we end up with things like infertility, allergies - to everything, fibromyalgia, etc....all these things that we didn't have to deal with decades ago. THERE IS A REASON!

I'm not saying that sometimes there isn't a need for meds, but the VAST majority and I DO MEAN VAST MAJORITY of the time symptoms, circumstances, etc can be improved and even go away when proper nutrition to the body is adheared to. MEDS ARE THE LEADING CAUSE OF TOXICITY IN THE BODY. Is that what you REALLY want to do.........to you and your potential child???

I'd be looking at that as a LAST resort! Even "simple things" like PMS are altered drastically by diet!

I've never taken it, but I am taking Metformin which is for Poly Cystic Ovary Syndrome (PCOS), I'm not sure if this is related, but I either have to take Metformin to help me ovulate (and get pregnant), or Birth Control to ovulate (and not get pregnant). I always check out Rxlist.com before I take anything. Good luck!

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