Hey K.. We had the 2005 Pathfinder and it was hard with 2 small kids. Just maneuvering in a out w/ my newborn and 2 year old was pretty difficult. Parking spaces are so narrow these days that doors that swing out are hard to manage w/ small kids. And when you're trying to get kids into car seats, or especially when trying to remove an infant carrier from the base in the car, I found it to be often frustrating. I felt like I had to turn my children on their sides (while buckled in the infant carrier) just to be able to squeeze them through the space available when opening the door as wide as I could, trying not to bang up the car beside me. (Are you just looking at SUVs? I swore I would never drive a minivan, and would always drive an SUV, until we rented one while on vacation. They are MADE for people w/ young children. I swallowed my pride, and ended up loving mine.) Additionally, there were things about the Pathfinder that were just not well made: the seat cushions are *very* hard (I thought firm would be advantageous) and after more than 30 minutes in the car, I became very uncomfortable. The key fob is an engineering disaster. Very sensitive and so very easy to set off the car alarm when keys are in your pocket or bang up against something in your purse. We even called Nissan to see if they had updated the key fob and would send us a new one -- they didn't/wouldn't and even said they'd had a lot of calls . . .
Does the one you're looking at have running boards, to step up on to get into the car? We had to have some put on because it was really hard for me to get in -- although I'm not terribly short (abt. 5'4"), I was 8 months pregnant at the time we got it. But still needed a little boost to get in, even when not pregnant.
I'm sure there were more disadvantages. But that's about all I remember right now. The benefits that I miss about an SUV are cargo space, cargo space, and cargo space!! Plus being higher up off of the ground was a benefit to me as well.
Hope this helps!
After re-reading, I see that you've had a minivan, so you know all about them! Good luck making your decision!